Endocrine Abstracts

Thyroidal pain is usually due to subacute thyroiditis. It seldom occurs in patients with Hashimoto’s thyroiditis (HT), and then its name is painful HT (PHT). Differently from subacute thyroiditis, occasional PHT patients show no benefit from medical treatment so that thyroidectomy is frequently needed. We report two women diagnosed of PTH and successfully treated with intrathyroidal corticosteroid injection after initial unsuccessful treatment with L-thyroxine replacement...

Adrenal venous sampling (AVS) is regarded as the gold-standard for the study of lateralisation of primary aldosteronism (PA) after its biochemical diagnosis. After catheterisation of both adrenal veins, confirmed by ratio of cortisol concentration in each adrenal vein and peripheral vein (selectivity index (SI)), lateralization is accepted if aldosterone/cortisol (A/C) ratio between both adrenal veins is over 3–4 (lateralization index (LI)), particularly if non-dominant v...

Primary hyperparathyroidism (PHP) is a common endocrine disorder. It is due to a single parathyroid adenoma in 80% of cases, most of the remainder due to hyperplasia of all four parathyroid glands. The only curative procedure is parathyroidectomy, but preoperative localization can be difficult. Isotope scanning with sestaMIBI is considered to be useful in localizing any parathyroid adenoma to help guided surgery. The aim of this study is demonstrated the influence of biochemic...

In postmenopausal women with clinical hyperandrogenism Cushing’s syndrome and adrenal/ovarian neoplasms must be excluded, but radiological and biochemical studies are not always useful for localizing the source of androgens.Case 1: A 75-year-old woman developed alopecia and progressive hair growth on the chest and abdomen over 4 months. Five years before a successful parathyroidectomy had been carried out. Hormonal evaluation: Testosterone (T): 5.84...

BackgroundSuspicion of Cushing´s syndrome (CS) is usually suggested by non-specific clinical data. Chronic hypercortisolism associates changes in white blood cell count (WBC), essentially a higher count with relative lymphopenia. Our purpose is to investigate the prevalence of these findings among a local series of patients with Cushing’s syndrome before and after the hypercortisolism revertion to assess the diagnostic value of these parameters...

Introduction: Most recent ATA thyroid nodule/DTC guidelines recommend thyroidectomy without prophylactic CND for small (T1 or T2), non-invasive, clinically node-negative PTC (cN0). However, some studies have suggested an association between the BRAFV600E mutation and the risk of nodal disease. Moreover, BRAF V600E mutation have recently showed significant association with recurrence in solitary intrathyroidal PTC between 2 and 4 cm (pT2) making suitable a more aggressive treat...

Secondary endocrine hypertension affects around 10% of all hypertensive population, most frequently primary aldosteronism (PA). Less frequent forms of adrenal hypertension include pheochromocytomas and other causes of mineralocorticoid excess than PA, featuring suppressed renin without excess of aldosterone. Featuring. We present a 29-year-old woman with difficult to control hypertension diagnosed two years before and poor response to ACEI and ARA II treatment. She was referre...

Introduction: Subclinical hypercortisolism (SH), a condition of biochemical cortisol excess without the classical signs or symptoms of overt hypercortisolism, is thought to be present in the 5–30% of patients with incidentally discovered adrenal mass (adrenal incidentalomas). Some evidence suggest that this condition may lead to long-term consequences of cortisol excess, but indication and potential benefits of adrenalectomy in this state are still in doubt. We analyse a ...

Objective: To compare the results of immunohistochemistry (IHC) and DNA sequencing in detection of BRAF V600E mutation in papillary thyroid carcinomas (PTC). BRAF V600E mutation is the most common genetic alteration in papillary thyroid carcinomas and is associated with worse prognosis. Direct sequencing is usually performed, but less expensive immunohistochemistry can be used instead.Methods: Study was performed in 54 consecutive PTCs during 2014–2...

In our centre we use CNB for routine study of thyroid nodules since 2005. Four diagnostic categories for CNB’s results have been standardised: insufficient; benign; follicular proliferation (FOL), including follicular and oncocytic neoplasms; and malignant. Diagnosis of FOL was defined according to the presence of microfollicular patterned biopsies with scant or absent colloid, sometimes with minimal pleomorphism or discrete nuclear changes. This category could be equival...